Exploring Angiogenesis and Cerebral Blood Flow in Early Alzheimer’s Disease

In this episode, coauthors Dr. Bing Xin Song and Dr. Krista L. Lanctôt give a snapshot of their recently published manuscript, "Vascular Endothelial Growth Factor and Regional Cerebral Blood Flow in Early Alzheimer’s Disease." Building on past in vitro and in vivo studies, their work highlights a compelling link between angiogenesis and cerebral blood flow (CBF) in individuals with early-stage Alzheimer’s disease. Using a combination of neuroimaging and neurophysiology techniques, the study reveals a significant association between circulating vascular endothelial growth factor (VEGF) and regional CBF. 

 

Vascular endothelial growth factor and regional cerebral blood flow in early Alzheimer’s disease

Bing Xin Song, Guocheng Jiang, Melissa Wong, Damien Gallagher, Bradley J. MacIntosh, Ana C. Andreazza, Erika L. Beroncal, Sandra E. Black, Nathan Herrmann, Jocelyn Charles, Fuqiang Gao, Alex Kiss, Giovanni Marotta, and Krista L. Lanctôt

Journal of Neurophysiology 2025 133:3, 924-929