September 13, 2017
There is currently no reliable reversal agent for general anesthesia. However, recent work has shown that three drugs that elevate intracellular cAMP (forskolin, theophylline, and caffeine) accelerate emergence from anesthesia in rats. In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Jimmy Xie, Robert Fong, and Aaron Fox (all from the University of Chicago) about a new study that shows that caffeine is effective even at high levels of anesthetic, and which explores the mechanisms underlying this finding.
Caffeine accelerates recovery from general anesthesia via multiple pathways
Robert Fong, Suhail Khokhar, Atif N. Chowdhury, Kelvin G. Xie, Josiah Hiu-Yuen Wong, Aaron P. Fox, Zheng Xie
Journal of Neurophysiology, published online September 1, 2017. DOI: 10.1152/jn.00393.2017.
August 29, 2017
How can the common synaptic input to a pool of motor neurons be quantified? In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dan Feeney (University of Colorado, Boulder) about the history of quantifying common motor input, a new state-space model approach to the problem, and the experimental findings which validated this model.
A latent low-dimensional common input drives a pool of motor neurons: a probabilistic latent state-space model
Daniel F. Feeney, Francois G. Meyer, Nicholas Noone, Roger M. Enoka
Journal of Neurophysiology, published online August 2, 2017. DOI: 10.1152/jn.00274.2017.
July 24, 2017
Could fetal ethanol exposure (FAE) affect the way that the taste system responds to ethanol and other flavor components of alcohol? Might this play a role in the increased risk of alcohol abuse following FAE? In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Steven Youngentob (University of Tennessee Health Science Center) and John Glendinning (Barnard College, Columbia University) about the history, recent progress, and future of their work exploring taste response to alcohol in rats.
Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components
John I. Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P. Bryant, Lisa Youngentob, Steven L. Youngentob
Journal of Neurophysiology, published online May 10, 2017. DOI: 10.1152/jn.00108.2017.
June 30, 2017
Could learning the Tango really help patients with Parkinson's disease? And how could this improvement be quantified? In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with the authors of a recent study which used motor module analysis to identify "clinically meaningful improvements on behavioral measures of balance, gait, and disease symptoms after three-weeks of daily Adapted Tango classes". Listen to learn more!
Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson's disease
Jessica L. Allen, J. Lucas McKay, Andrew Sawers, Madeleine Eve Hackney, Lena H. Ting
Journal of Neurophysiology, published online April 5, 2017. DOI: 10.1152/jn.00813.2016.
June 7, 2017
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, disrupting autonomic function. The progressive loss of adequate neural conduction in MS has been shown to cause a wide range of symptomatology, with many patients experiencing a profound heat intolerance known as Uhthoff’s phenomenon. Yet little progress has been made in regards to understanding the effect of MS on the control of thermoregulatory reflex responses, such as skin blood flow and sweating. In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) and content expert Matthew Muller (Penn State Hershey Heart and Vascular Institute) talk with authors Scott Davis (Southern Methodist University) and Dustin Allen (Southern Methodist University) about their work examining the reflex control of thermoregulatory responses to a passive heat stress in individuals with MS. What are some of the challenges facing these types of studies, and what are the next steps to advance this area of research? Listen and find out.
Impaired sweating responses to a passive whole-body heat stress in individuals with multiple sclerosis
Dustin R. Allen, Mu Huang, Iqra M. Parupia, Ariana R. Dubelko, Elliot M. Frohman, Scott L. Davis
Journal of Neurophysiology, published online March 8, 2017. DOI: 10.1152/jn.00897.2016.
May 5, 2017
Age-related cognitive and neural decline begins in healthy adults in the third decade of life and continues throughout advanced aging. Developing support strategies to prevent declines in brain health and achieve a better quality of life in later years requires identification of the cortical sites and patterns of these age-related neurological changes. In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) and Associate Editor Sean Stocker (University of Pittsburgh) talk with author Katelyn Wood (University of Western Ontario) about some of the surprising findings in this study exploring the relationship between cardiorespiratory fitness and forebrain circuitry associated with cardiovascular control. What does this study tell us about the impact of cardiorespiratory fitness on cardiac and neural responses in healthy, middle- to older-aged adults? Listen and find out.
High cardiorespiratory fitness in early to late middle age preserves the cortical circuitry associated with brain-heart integration during volitional exercise
Katelyn N. Wood, Torri A. Luchyshyn, J. Kevin Shoemaker
Journal of Neurophysiology, published online April 1, 2017. DOI: 10.1152/jn.00592.2016 .
April 6, 2017
Our knowledge of the molecular mechanisms underlying signaling of mechanical stimuli by muscle spindles is incomplete. In particular, the ionic conductances that sustain tonic firing during static muscle stretch are unknown. In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with researchers Tim Cope (Georgia Institute of Technology) and Dario Carrasco (Georgia Institute of Technology) about their work looking at the distribution of voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. Is it possible that voltage-gated sodium channels contribute to multiple steps in sensory signaling by muscle spindles? What do their findings tell us and where will they lead to next? Listen and find out.
Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles
Dario Ivan Carrasco, Jacob A. Vincent, Timothy C. Cope
Journal of Neurophysiology, published online January 25, 2017. DOI: 10.1152/jn.00889.2016 .
March 23, 2017
Our ability to process the number of events over time, so-called temporal frequency information, allows us to discriminate surface textures by touch or listen to a conversation in a noisy environment. Studies have actually shown that sounds can alter our detection of vibrations and even our subjective experience of textures. How does what we are hearing affect our brain's ability to understand what our hands are feeling? In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh), Associate Editor Christos Constantinidis (Wake Forest University), and content expert Carmel Levitan (Occidental College) talk with author Jeff Yau (Baylor College of Medicine) about his work investigating auditory adaptation and tactile frequency perception. Could it be that the neural circuits supporting tactile frequency perception also process auditory signals? Listen and find out.
Auditory adaptation improves tactile frequency perception
Lexi E. Crommett, Alexis Pérez-Bellido, Jeffrey M. Yau
Journal of Neurophysiology, published online January 11, 2017. DOI: 10.1152/jn.00783.2016 .
February 14, 2017
In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Davide Filingeri (Loughborough University, UK) about his research into understanding how the human body interacts with our surrounding thermal environments, both physiologically (e.g. body temperature regulation) and perceptually (e.g. perception of temperature, wetness, touch and pain), and on how neurological diseases (e.g. Multiple Sclerosis) alter these physiological functions.
Characteristics of the local cutaneous sensory thermo-neutral zone
Davide Filingeri, Hui Zhang, Edward A. Arens
Journal of Neurophysiology, published online February 1, 2017. DOI: 10.1152/jn.00845.2016 .
February 6, 2017
Schizophrenia is a debilitating psychiatric disorder that manifests in early adulthood. Disrupted-in-schizophrenia-1 (DISC1), a susceptible gene for schizophrenia implicated in neuronal development, brain maturation, and neuroplasticity, is a promising candidate gene for schizophrenia, but the molecular mechanisms underlying its role in the pathogenesis of the disease are still poorly understood. In this podcast, Editor-in-Chief Bill Yates (University of Pittsburgh) and Associate Editor Sean Stocker (University of Pittsburgh) talk with author Brian Head (VA San Diego and University of California, San Diego) about the role of caveolin-1, a cholesterol binding and scaffolding protein that regulates neuronal signal transduction and promotes neuroplasticity, in mediating DISC1 expression in neurons in vitro and the hippocampus in vivo. Could this work lead to new treatments for schizophrenia? Listen and find out.
Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia
Adam Kassan, Junji Egawa, Zheng Zhang, Angels Almenar-Queralt, Quynh My Nguyen, Yasaman Lajevardi, Kaitlyn Kim, Edmund Posadas, Dilip V. Jeste, David M. Roth, Piyush M. Patel, Hemal H. Patel, Brian P. Head
Journal of Neurophysiology, published online November 2, 2016. DOI: 10.1152/jn.00481.2016 .