May 21, 2021
In this podcast Editor in Chief Nino Ramirez discusses JNP’s new article type Neurovision with Prof. John Krakauer of Johns Hopkins University and Prof. Reza Shadmehr of Johns Hopkins University. Neurovision articles aim to move science forward and point out bottlenecks in our understanding of the field. They resemble review articles, but with the inclusion of original data. The presence of new original data is meant to inspire new experiments and ideas. These articles will serve as blueprints, and guides for future research. JNP is inviting leading neuroscientists to write articles in this format, which will serve as templates moving forward.
For more information on the Journal of Neurophysiology's manuscript types click here: https://journals.physiology.org/jn/article-types
May 7, 2021
In this podcast Dr. Greg Horwitz of the University of Washington discuses double-opponent cells in macaque area V1, a class of neurons that respond to spatial chromatic contrast in visual scenes. What information they carry is debated because their receptive field organization has not been characterized thoroughly. Using white noise analysis and statistical model comparisons, De and Horwitz show that many double-opponent receptive fields can be captured by either a Gabor model or a center-with-an-asymmetric-surround model but not by a difference-of-Gaussians model.
Read the article here:
March 12, 2021
In this episode Editor in Chief Prof. Ramirez is joined by Prof Stroh of the University of Mainz and Prof. Totah of the University of Helsinki to discus the manuscript titled "Synchronous spiking associated with prefrontal high gamma oscillations evokes a 5 Hz-rhythmic modulation of spiking in locus coeruleus." Prof. Nelson Totah highlights the main conceptual advances in their paper and talks about what motivated them to focus on top down control exerted by PFC on LC. The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and prefrontal stimulation studies demonstrated the potential for PFC-LC interactions; however, it is unknown what types of PFC activity affect the LC. In this podcast, the author talks about the transient increases in PFC high gamma power and associated changes in PFC unit-pair synchrony that are a potential sign of top-down control over the LC.
Nelson K. Totah, Nikos K. Logothetis, Oxana Eschenko
Also discussed: McCormick, D. A., Nestvogel, D. B. & He, B. J. Neuromodulation of Brain State and Behavior. Annu Rev Neurosci 43, 1–25 (2020)
March 3, 2021
The topographic organization of skilled movements seem to be particularly plastic. The author describes how they addressed this issue in their study, and what methods they used. The motor cortex is topographically organized into maps of different body parts. We used to think that the function of motor cortex was to drive individual muscles, but more recently we have learned that it is also organized to make complex movements. In this podcast Prof. Cam Teskey of the University of Calgary discuses in detail the emergence and topography of complex movement representation, as well as their plasticity during development.
Anna C. Singleton, Andrew R. Brown & G. Campbell Teskey
February 26, 2021
What does it take to recover walking after a spinal cord injury? If you could replicate this supraspinal control – what aspects would you need? In this podcast Prof Sten Grillner talks about the spinal mechanisms that coordinate locomotion and the interaction between the different sensory mechanisms that help coordinate the locomotor movements and the central locomotor network.
February 16, 2021
In this podcast, Editor-in-Chief, Nino Ramirez talks with Dr. Marc Schmidt (University of Pennsylvania) about his Research Article which explores recent theories of norepinephrine (NE) function regarding the stimulation of the norepinephrine function that NE can act directly on the motor system to influence the transition between exploratory and exploitative behavioral strategies. Learn how the songbird can act directly on a "cortical" motor area and cause a switch between exploratory and exploitative behavior. Read the article:
"Regulation of vocal precision by noradrenergic modulation of a motor nucleus"
Marc F Schmidt, Zachary Phillip Sheldon, Christina B. Castelino, Chris M. Glaze, Steve Bibu, Elvina Yau
February 16, 2021
Have you ever wondered how the brain encodes information? How do you crack a code produced within the brain? What are the changes in practicing and performing during development and aging? In this podcast the authors talk about the differences between practice and performance. Be sure to listen to the end for our special guest.
S. E. Palmer, B. D. Wright, A. J. Doupe, and M. H. Kao
Read the article here: https://doi.org/10.1152/jn.00034.2019 @neuroscience
January 26, 2021
In this podcast Editor in Chief Nino Ramirez interviews first author Justine Clery and senior author Stefan Everling about an insightful new Research Article by Clery et al. Learn more about the advantages of the marmosets as a primate model system for studying primate neuroscience. The authors talk about using somatosensory stimulation combined with functional MRI in awake marmosets to reveal the topographic body representation in areas S1, S2, thalamus and putamen. They showed the existence of a body representation organization within the thalamus and the cingulate cortex by computing functional connectivity maps from seeds defined in S1/S2 using resting-state fMRI data. This non-invasive approach will be essential for chronic studies by guiding invasive recording and manipulation techniques.
@JustineClery @Yuki26147815 @andpru #neuroscience
December 10, 2020
Have you ever wondered how the brain controls reaching movements, whether mice can perfect a reaching movement and cease making errors, which would resemble a “hot-hand” a phenomenon that has been proposed and discussed in Basketball. What about perfecting reaching movements in the violin? In this podcast Editor-in-Chief Nino Ramirez talks with Dr. Abby Person (University of Colorado), senior author of the study entitled “online control of reach accuracy in mice”. This study uses statistical machine learning and kinematic characterization to identify the canonical features of reaching movements that are conserved in mice and primates. Read the article here: https://doi.org/10.1152/jn.00324.2020 @personal_neuro
October 14, 2020
In this podcast, new Editor-in-Chief Nino Ramirez talks with Dr. Monica Gorassini (University of Alberta) about her recent article which employed a "new method of estimating synaptic drive to multiple, simultaneously recorded motor units" in order to explore the contribution of persistent inward currents to self-sustained firing across motoneuron size. This article was also featured in August's issue of APSselect!
"Estimation of self-sustained activity produced by persistent inward currents using firing rate profiles of multiple motor units in humans"
Babak Afsharipour, Nagib Manzur, Jennifer Duchcherer, Keith F. Fenrich, Christopher K. Thompson, Francesco Negro, Katharina A. Quinlan, David J. Bennett, and Monica A. Gorassini
Published online June 26, 2020.