February 16, 2021
In this podcast, Editor-in-Chief, Nino Ramirez talks with Dr. Marc Schmidt (University of Pennsylvania) about his Research Article which explores recent theories of norepinephrine (NE) function regarding the stimulation of the norepinephrine function that NE can act directly on the motor system to influence the transition between exploratory and exploitative behavioral strategies. Learn how the songbird can act directly on a "cortical" motor area and cause a switch between exploratory and exploitative behavior. Read the article:
"Regulation of vocal precision by noradrenergic modulation of a motor nucleus"
Marc F Schmidt, Zachary Phillip Sheldon, Christina B. Castelino, Chris M. Glaze, Steve Bibu, Elvina Yau
February 16, 2021
Have you ever wondered how the brain encodes information? How do you crack a code produced within the brain? What are the changes in practicing and performing during development and aging? In this podcast the authors talk about the differences between practice and performance. Be sure to listen to the end for our special guest.
S. E. Palmer, B. D. Wright, A. J. Doupe, and M. H. Kao
Read the article here: https://doi.org/10.1152/jn.00034.2019 @neuroscience
January 26, 2021
In this podcast Editor in Chief Nino Ramirez interviews first author Justine Clery and senior author Stefan Everling about an insightful new Research Article by Clery et al. Learn more about the advantages of the marmosets as a primate model system for studying primate neuroscience. The authors talk about using somatosensory stimulation combined with functional MRI in awake marmosets to reveal the topographic body representation in areas S1, S2, thalamus and putamen. They showed the existence of a body representation organization within the thalamus and the cingulate cortex by computing functional connectivity maps from seeds defined in S1/S2 using resting-state fMRI data. This non-invasive approach will be essential for chronic studies by guiding invasive recording and manipulation techniques.
@JustineClery @Yuki26147815 @andpru #neuroscience
December 10, 2020
Have you ever wondered how the brain controls reaching movements, whether mice can perfect a reaching movement and cease making errors, which would resemble a “hot-hand” a phenomenon that has been proposed and discussed in Basketball. What about perfecting reaching movements in the violin? In this podcast Editor-in-Chief Nino Ramirez talks with Dr. Abby Person (University of Colorado), senior author of the study entitled “online control of reach accuracy in mice”. This study uses statistical machine learning and kinematic characterization to identify the canonical features of reaching movements that are conserved in mice and primates. Read the article here: https://doi.org/10.1152/jn.00324.2020 @personal_neuro
October 14, 2020
In this podcast, new Editor-in-Chief Nino Ramirez talks with Dr. Monica Gorassini (University of Alberta) about her recent article which employed a "new method of estimating synaptic drive to multiple, simultaneously recorded motor units" in order to explore the contribution of persistent inward currents to self-sustained firing across motoneuron size. This article was also featured in August's issue of APSselect!
"Estimation of self-sustained activity produced by persistent inward currents using firing rate profiles of multiple motor units in humans"
Babak Afsharipour, Nagib Manzur, Jennifer Duchcherer, Keith F. Fenrich, Christopher K. Thompson, Francesco Negro, Katharina A. Quinlan, David J. Bennett, and Monica A. Gorassini
Published online June 26, 2020.
August 12, 2020
How does a common Parkinson's Disease-linked mutation affect stress response? In this podcast, Editor-in-Chief Bill Yates talks with Christopher Guevara, Dr. Bridget Matikainen-Ankney, Dr. Deanna Benson, and Dr. George Huntley (Icahn School of Medicine at Mount Sinai) about their Rapid Report article, which explored this question in a mouse model of the LRRK2-G2019S mutation. Listen to learn about evidence of how "G2019S alters the magnitude and direction of behavioral responses to stress that may reflect unique modifications of adaptive plasticity in cells and circuits implicated in psychopathology in humans."
LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress
Christopher A. Guevara,* Bridget A. Matikainen-Ankney,* Nebojsa Kezunovic, Katherine LeClair, Alexander P. Conway, Caroline Menard, Meghan E. Flanigan, Madeline Pfau, Scott J. Russo, Deanna L. Benson,* and George W. Huntley, Published online June 16, 2020.
April 20, 2020
In this podcast, Editor-in-Chief Bill Yates talks with Dr. Andrea Meredith and Dr. Hans Moldenhauer about their article which compares the effects of different mutations (N999S and D434G) which are associated with the recently-identified neurological disorder called KCNMA1-linked channelopathy. This research was also featured in Episode 4 of the Netflix and New York Times documentary series Diagnosis. Listen to learn about BK channels, gain-of-function mutations, and important clinical implications of this research!
Comparative gain-of-function effects of the KCNMA1-N999S mutation on human BK channel properties
Hans J. Moldenhauer, Katia K. Matychak, and Andrea L. Meredith, Published online February 4, 2020.
January 29, 2020
What exactly is corporeal awareness, and how does breathing contribute to this form of self-consciousness? In this podcast, Editor-in-Chief Bill Yates talks with Alessandro Monti, Dr. Giuseppina Porciello, Dr. Gaetano Tieri, and Dr. Salvatore M. Aglioti (Sapienza Università di Roma and IRCCS Fondazione Santa Lucia) about their Rapid Report article, which combined respiration recordings with immersive virtual reality to explore this question. Listen to learn about the embreathment illusion, which emerged from this unique experimental design.
The “embreathment” illusion highlights the role of breathing in corporeal awareness
Alessandro Monti, Giuseppina Porciello, Gaetano Tieri, and Salvatore M. Aglioti, Published online January 17, 2020.
September 24, 2019
How does estradiol acutely facilitate sex differences in striatum-dependent behaviors? In this podcast, Editor-in-Chief Bill Yates talks with Dr. Amanda Krentzel and Dr. John Meitzen (both from North Carolina State University) about their study which investigated this question in adult rats. Listen to learn about sex differences, medium spiny neurons, glutamatergic signaling, and more.
Also be sure to check out the parallel episode of The Brain That Named Itself podcast, which discusses this study in a way that is acessible to non-scientists: https://brainthatnameditself.com/episode-14-science-interlude
Estradiol rapidly modulates excitatory synapse properties in a sex- and region-specific manner in rat nucleus accumbens core and caudate-putamen
Amanda A. Krentzel, Lily R. Barrett, and John Meitzen
Journal of Neurophysiology, Published online September 13, 2019.
September 18, 2019
The "interference effect" occurs during a bimanual response when one hand is abruptly cued to stop, resulting in a significant delay in the actions of the other hand. But what neural mechanisms underlie this effect? In this podcast, Editor-in-Chief Bill Yates talks with Corey Wadsley, Dr. John Cirillo, and Dr. Winston Byblow (all from the University of Auckland) about their recent article, which investigates whether the interference effect is the consequence of between-hand coupling. Listen to learn about the role of GABA-mediated networks, movement preparation, paradoxical findings and more!
Between-hand coupling during response inhibition
Corey George Wadsley, John Cirillo, and Winston D Byblow
Journal of Neurophysiology, Published online July 24, 2019.