Higher hyperpolarization activated current (Ih) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X mice

In this episode, coauthor Lauren Hewitt discusses her recently published study, “Higher hyperpolarization activated current (I_h) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X mice.” The research examines how inhibitory interneurons are altered in a fragile X mouse model, revealing that increased Ih current reduces the excitability of a specific interneuron subtype. These findings highlight how changes in voltage-gated ion channel function can disrupt the brain’s excitatory/inhibitory balance, offering new insights into circuit dysfunction in fragile X syndrome.

 

Higher hyperpolarization-activated current in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of fragile X mice

 

Lauren T. Hewitt, Alyssa M. Marron, and Darrin H. Brager

Journal of Neurophysiology 2025 133:5, 1558-1571