JNP Micro Podcasts ”Four Questions”: Adalee J. Lube, and Bruce A. Carlson

Adalee J. Lube and Bruce Carlson of Washington University in St. Louis discuss their recently published manuscript "Spike timing-dependent plasticity alters electrosensory neuron synaptic strength in vitro but does not consistently predict changes in sensory tuning in vivo" in our newest micro podcast series. 

 

NEW & NOTEWORTHY We replicated behaviorally relevant temporal patterns of synaptic activity in vitro and used the same patterns during sensory stimulation in vivo. There was a Hebbian spike timing-dependent plasticity (STDP) pattern in vitro, but sensory responses in vivo did not shift according to STDP predictions. Analysis suggests that this disparity is influenced by differences in polysynaptic activity, including inhibitory interneurons. These results suggest that STDP rules at synapses in vitro do not necessarily apply to circuits in vivo.

 

Citation:

Spike timing-dependent plasticity alters electrosensory neuron synaptic strength in vitro but does not consistently predict changes in sensory tuning in vivo

Adalee J. Lube, Xiaofeng Ma, and Bruce A. Carlson

Journal of Neurophysiology 2023 129:5, 1127-1144