JNP Micro Podcasts ”Four Questions”: Todd P. Silverstein

In this podcast Dr. Todd Silverstein of Willamette University discusses his recently published review titled "Lee’s “Transmembrane Electrostatically-Localized Proton” model does NOT offer a better understanding of neuronal transmembrane potentials." 

 

NEW & NOTEWORTHY In this manuscript I critique a 2020 J. Neurophysiol. paper by James W. Lee. His TELP hypothesis 1) mispredicts the resting neuron’s excess of external chloride; 2) predicts the preponderance of surface H⁺ over Na⁺ using ΔG° rather than ΔG; 3) mispredicts the dependence of the neuronal resting potential on external [Na⁺], [K⁺], and [Cl⁻]; 4) neither cites experimental results nor proposes experiments to test his hypothesis; and 5) presents a problematic characterization of the purpose of myelin.

 

Article Citation:

Lee’s “Transmembrane Electrostatically-Localized Proton” model does NOT offer a better understanding of neuronal transmembrane potentials

Todd P. Silverstein

Journal of Neurophysiology 2023 130:1, 123-127