JNP Micro Podcasts: Impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy

In this episode, coauthor Arun V. Krishnan highlights the article titled "Impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy." Diabetic peripheral neuropathy is known to be relentlessly progressive and irreversible. Prospective studies in 24 participants with diabetic peripheral neuropathy (DPN) treated with glucagon-like peptide-1 receptor agonists (GLP-1RA) demonstrated improvements in clinical neuropathy scores, nerve conduction studies, and axonal excitability recordings. Analysis of axonal excitability recordings revealed the mechanism for GLP-1RA improvement in DPN were changed consistent with improvements in Na⁺/K⁺–ATPase pump function, and this was supported by mathematical modeling.

 

Impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy

Roshan Dhanapalaratnam, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Natalie C. G. Kwai, and Arun V. Krishnan

Journal of Neurophysiology 2025 133:1, 14-21