Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2 deficient mice

In this podcast Editor in Chief Nino Ramirez and senior author, Professor Haouzi of Pennsylvania State University discuss the paper titled “Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2 deficient mice”. When life-threatening doses of fentanyl are used in mice, the beta-arrestin2 pathway appears to play a critical role in the recovery from an opioid overdose. This observation calls into question the use of G protein-biased μ-opioid receptor agonists, as a strategy for safer opioid analgesic drugs.

Check out the article here:  https://journals.physiology.org/doi/abs/10.1152/jn.00711.2020 

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