Synchronous spiking associated with prefrontal high gamma oscillations evokes a 5 Hz-rhythmic modulation of spiking in locus coeruleus

In this episode Editor in Chief Prof. Ramirez is joined by Prof Stroh of the University of Mainz and Prof. Totah of the University of Helsinki to discus the manuscript titled "Synchronous spiking associated with prefrontal high gamma oscillations evokes a 5 Hz-rhythmic modulation of spiking in locus coeruleus." Prof. Nelson Totah highlights the main conceptual advances in their paper and talks about what motivated them to focus on top down control exerted by PFC on LC. The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and prefrontal stimulation studies demonstrated the potential for PFC-LC interactions; however, it is unknown what types of PFC activity affect the LC. In this podcast, the author talks about the transient increases in PFC high gamma power and associated changes in PFC unit-pair synchrony that are a potential sign of top-down control over the LC.

Nelson K. Totah, Nikos K. Logothetis, Oxana Eschenko

Also discussed: McCormick, D. A., Nestvogel, D. B. & He, B. J. Neuromodulation of Brain State and Behavior. Annu Rev Neurosci 43, 1–25 (2020)

 

https://doi.org/10.1152/jn.00677.2020