Uncovering a New Aβ Receptor: A Key to Controlling Neuronal Hyperactivity in Alzheimer’s Disease

In this episode of the Journal of Neurophysiology's podcast series, we spotlight the research titled “Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability.”

Alzheimer’s disease is well known for memory loss and cognitive decline—but behind these symptoms lies a web of complex neuronal dysfunction. This study reveals that amyloid beta peptides (Aβs), known to enhance sodium channel activity and drive hyperexcitability, exert their effects via an unexpected molecular player: the type I taste receptor, T1R2/T1R3.

Using advanced patch-clamp techniques, the researchers identified this novel Aβ receptor, opening a promising new path for therapeutic intervention. By targeting this receptor, future treatments may be able to reduce Aβ-induced hyperactivity and slow AD progression.

 

Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability

Mitsuyoshi Luke Saito, Tsutomu Sasaki, and Mariko Ruth Saito

Journal of Neurophysiology 2025 133:6, 1861-1885