Episodes
Friday Oct 22, 2021
Friday Oct 22, 2021
How do factors like advancing age and hearing loss impact auditory processing in the human brain? In this podcast, author Dr. Jana Van Canneyt of the University of Leuven discusses the recently published manuscript “Cortical compensation for hearing loss, but not age, in neural tracking of the fundamental frequency of the voice” with Editor in Chief Prof. Nino Ramirez. Previous studies disagree on the effects of age and hearing loss on the neurophysiological processing of the fundamental frequency of the voice (f0), in part due to confounding effects. Using a novel electrophysiological technique, natural speech stimuli, and controlled study design, we quantified and disentangled the effects of age and hearing loss on neural f0 processing. We uncovered evidence for underlying neurophysiological mechanisms, including a cortical compensation mechanism for hearing loss, but not for age.
Thursday Oct 07, 2021
Thursday Oct 07, 2021
What are the neuronal mechanisms that are the neuronal mechanisms implicated in Schizophrenia? Why is the SRKO mouse such a great model? How does it compare to other models of Schizophrenia in general and NMDA hypofunction in particular? In this podcast Editor in Chief Professor Nino Ramirez and author, Dr. John Gray (University of California, Davis) discusses his manuscript titled “Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction”. Recently, disruption of E/I balance has become an area of considerable interest for psychiatric research. Here, we report a reduction in inhibition in the serine racemase KO mouse model of schizophrenia that increases E/I balance and enhances synaptically-driven neuronal excitability. This reduced inhibition was driven cell-autonomously in pyramidal cells lacking serine racemase, suggesting a novel mechanism for how chronic NMDA receptor hypofunction can disrupt information processing in schizophrenia. Listen to learn more about this fascinating study.
Shekib A. Jami, Scott Cameron, Jonathan M. Wong, Emily R. Daly , A.
Kimberley McAllister, and John A. Gray
Read the manuscript here: https://doi.org/10.1152/jn.00661.2020
Friday Sep 10, 2021
Friday Sep 10, 2021
What types of proprioceptors are involved in insect locomotion? Insects have an exoskeleton, mammals have an endoskeleton. What are the implications for proprioception and locomotion in general? What are the advantages of studying proprioception in animals with an exoskeleton?
In this podcast, senior author Prof. Ansgar Buschges and first author Ms. Corinna Gebehart address these questions with Editor-in-Chief Prof. Nino Ramirez. They discuss their recently published manuscript, titled "Distributed Processing of Load and Movement Feedback in the Premotor Network Controlling an Insect Leg Joint."
Proprioception is crucial for motor control in legged animals. The authors show the extent to which processing of movement (fCO) and load (CS) signals overlaps in the local premotor network of an insect leg. Multimodal signals converge onto the same set of interneurons, and our knowledge about distributed, antagonistic processing is extended to incorporate multiple modalities within one perceptual neuronal framework.
https://journals.physiology.org/doi/abs/10.1152/jn.00090.2021
#Neuroscience #JNPPodcastSeries
Friday Aug 27, 2021
Friday Aug 27, 2021
Why is it important to study the cuneate nucleus/proprioception in the brain? In this podcast authors, Dr. Lee Miller and Mr. Christopher Versteeg talk with our guest host, Associate Editor Professor Robert Brownstone, about their recently published article on “Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.” The cuneate nucleus (CN) is the somatosensory gateway into the brain, and only recently has it been possible to record these signals from an awake animal. The authors recorded single CN neurons in monkeys and found proprioceptive CN neurons appear to receive input from very few muscles. In addition, the sensitivity of proprioceptive CN neurons to movement changes reliably during reaching, relative to passive arm perturbations. Sensitivity is generally increased, but not exclusively so, as though CN "spotlights" critical proprioceptive information during reaching. Is the CN affected by different receptor origins of signals and/or different muscles? Listen and find out.
Read the article here: https://doi.org/10.1152/jn.00568.2020
Friday Aug 20, 2021
Sodium sensitivity of KNa channels in mouse CA1 neurons
Friday Aug 20, 2021
Friday Aug 20, 2021
The Journal of Neurophysiology would like to dedicate the following podcast to Dr. Richard Gray. Dr. Gray passed away at the age of 68 on September 4, 2021.
How are potassium channels regulated? How ubiquitous are sodium-dependent potassium channels? In this podcast Editor-in-Chief Professor Nino Ramirez and authors Drs. Richard Gray and Daniel Johnston discuss their manuscript titled “Sodium sensitivity of KNa channels in mouse CA1 neurons.”. In this podcast, the authors discuss KNa channels in mouse hippocampal CA1 neurons. Excised inside-out patches showed the channels to be prevalent and active in most patches. Cell-attached recordings from intact neurons, however, showed little channel activity. Increasing cytoplasmic sodium in intact cells showed a small effect on channel activity compared to that seen in inside-out excised patches. Blockade of the Na+/K+ pump with ouabain, however, restored the activity of the channels to that seen in inside-out patches. The results emphasize the power of the Na+/K+ pump in maintaining a normally low concentration of intracellular Na+.
Sodium sensitivity of KNa channels in mouse CA1 neurons
Volume 125Issue 5 May 2021 DOI: 10.1152/jn.00064.2021
#neuroscience #JNPPodcastSeries
Monday Jul 12, 2021
Monday Jul 12, 2021
Auditory and visual information are processed differently by the brain, especially when it comes to space. In vision, the retina senses the locations of images with respect to where the eyes are pointing. In hearing, the cues our brains use to localize sound tell us where the sound is positioned with respect to the head and ears. How then do we perceive space as unified? In particular, how do our brains compensate for eye movements that constantly shift the relationship of the visual and auditory scenes?
In this podcast Editor in Chief Nino Ramirez and author Jennifer Groh discuss the manuscript titled “Compensating for a shifting world: evolving reference frames of visual and auditory signals across three multimodal brain areas” by Caruso et al. Models for visual-auditory integration posit that visual signals are eye-centered throughout the brain, while auditory signals are converted from head-centered to eye-centered coordinates. In the manuscript they show instead that both modalities largely employ hybrid reference frames: neither fully head- nor eye-centered. Across three hubs of the oculomotor network (intraparietal cortex, frontal eye field, and superior colliculus) visual and auditory signals evolve from hybrid to a common eye-centered format via different dynamics across brain areas and time.
Valeria C. Caruso, Daniel S. Pages, Marc A. Sommer, and Jennifer M. Groh
#neuroscience @jmgrohneuro
Check out the article here: https://doi.org/10.1152/jn.00385.2020
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Friday Jun 18, 2021
The Neurocene-Exploring Developments in the Field of Neuroscience
Friday Jun 18, 2021
Friday Jun 18, 2021
In this podcast Editor in Chief Nino Ramirez and Associate Editor Prof. John Krakauer discuss JNP’s new manuscript type the Neurocene. The Neurocene is a narrative that explores accelerating developments in the field of neuroscience, placing them in their historical and present context. Authors should provide a personalized and thoughtful viewpoint of a topic that does not seek to either provide definitive proof or a final conclusion.
This long-form scientific essay may focus on cultural currents, books and biography, philosophy and the history of science, and on puzzles, paradoxes, and controversies within the field of neuroscience itself. The article is meant to be inclusive, and the only stipulation is that the essay be written with longevity in mind - they should be read with equal pleasure and interest decades after their publication date.
For more information on the Journal of Neurophysiology's manuscript types click here: https://journals.physiology.org/jn/article-types
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Friday Jun 11, 2021
Friday Jun 11, 2021
In this podcast Editor in Chief Nino Ramirez and senior author, Professor Haouzi of Pennsylvania State University discuss the paper titled “Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2 deficient mice”. When life-threatening doses of fentanyl are used in mice, the beta-arrestin2 pathway appears to play a critical role in the recovery from an opioid overdose. This observation calls into question the use of G protein-biased μ-opioid receptor agonists, as a strategy for safer opioid analgesic drugs.
Check out the article here: https://journals.physiology.org/doi/abs/10.1152/jn.00711.2020
#neuroscience
Wednesday Jun 02, 2021
The effect of visual uncertainty on implicit motor adaptation
Wednesday Jun 02, 2021
Wednesday Jun 02, 2021
What is sensorimotor adaptation? Why do the authors use this term rather than motor learning? What are some of the key features of sensorimotor adaptation, and in particular, why is the focus here on error-based learning? How do the author's results change the way we think about how visual uncertainty impacts adaptation?
Out of the University of California, Professor Richard Ivry and JT Tsay discuss their recently published manuscript titled “The effect of visual uncertainty on implicit motor adaptation.” Sensorimotor adaptation is influenced by both the size and variance of error information. In the present study, we varied visual uncertainty and error size in a factorial manner and evaluated their joint effect on adaptation, using a feedback method that avoids inherent limitations with standard visuomotor tasks. Uncertainty attenuated adaptation but only when the error was small. This striking interaction highlights a novel constraint for models of sensorimotor adaptation.
Check out the article here: https://journals.physiology.org/doi/full/10.1152/jn.00493.2020
#neuroscience #JNPPodcastSeries
Tuesday May 25, 2021
Music-selective neural populations arise without musical training
Tuesday May 25, 2021
Tuesday May 25, 2021
What features of a sound does the brain perceive as a pitch? What is the role of rhythm in music? In this podcast Dr. Nancy Kanwisher ( Massachusetts Institute of Technology) and PhD candidate Dana Boebinger (Harvard University) discuss how music-selective neural populations are clearly present in people without musical training, demonstrating that they are a fundamental and widespread property of the human brain. The authors then discuss how music-selective neural populations respond strongly to music from unfamiliar genres as well as music with rhythm but little pitch information, suggesting that they are broadly responsive to music as a whole.
Read the article here: https://doi.org/10.1152/jn.00588.2020
#neuroscience