JNP Micro Podcast: Onion Skin or AHP firing scheme?

In this podcast, coauthor Mohamed H. Mousa highlights the newly published research titled "Onion skin is not a universal firing pattern for spinal motoneurons: simulation study." The study reports two contrasting schemes, namely the "onion skin" and the "AHP" regarding the relationship between MUs firing rates and recruitment order. Previous studies have examined these schemes phenomenologically, imposing one scheme on the firing-recruitment relationship. Here, the authors employed a high-fidelity computational model that prioritizes biological fidelity and heterogeneity to investigate motoneuron firing schemes without bias towards either scheme. Their objective findings offer an explanation for the longstanding dichotomy on MU firing patterns.

 

Article Citation:

Onion skin is not a universal firing pattern for spinal motoneurons: simulation study

Mohamed H. Mousa, Nathan P. Wages, and Sherif M. Elbasiouny

Journal of Neurophysiology 2024 132:1, 240-258