JNP Micro Podcasts: Exploring Amiloride's Impact on Baroreflex Sensitivity and Blood Pressure Variability in Healthy Young Adults

In this episode of the Journal of Neurophysiology's Podcast Series, coauthor Igor A. Fernandes discusses the research titled "Does a Single Oral Administration of Amiloride Affect Spontaneous Arterial Baroreflex Sensitivity and Blood Pressure Variability in Healthy Young Adults?" This study builds on preclinical models that suggest amiloride (AMD), a nonselective antagonist of acid-sensing ion channels (ASICs), may impair baroreflex sensitivity and disrupt blood pressure regulation. Igor explains how the research team translated these findings to human subjects, investigating the effects of acute oral ingestion of AMD on blood pressure variability and baroreflex sensitivity in healthy young adults. Surprisingly, the study found that, contrary to preclinical evidence, AMD did not impair spontaneous arterial baroreflex sensitivity or blood pressure variability in humans. Tune in to explore the implications of these findings for understanding blood pressure regulation and the role of ASICs in humans.

 

Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?

Igor A. Fernandes, Jon Stavres, Takuto Hamaoka, Qudus A. Ojikutu, Jeann L. Sabino-Carvalho, Lauro C. Vianna, J. Carter Luck, Cheryl Blaha, Aimee E. Cauffman, Paul C. Dalton, Michael D. Herr, Victor Ruiz-Velasco, Zyad J. Carr, Piotr K. Janicki, and Jian Cui

Journal of Neurophysiology 2024 132:3, 922-928